Generated 2026-06-11. May 2026 values: Quest specimen HZ452364U, collected 05/26/2026, reported 05/31/2026, ordered by Joshua Emdur, D.O. (Function Health). Jan 2025 values: Quest draw collected 01/10 to 01/11/2025, as recorded in the report's Previous Result column and her health profile. PDF archived in Drive Health/Alyssa (file ID 176KuWrvvFF5soj1GR7GsMGd2PPM7Eiim).
LDL Particle Number
971
was 1707 High, now Optimal (<1138)
Small LDL
131
was 281 High, now Optimal (<142)
ANA Screen
1:40
Positive, speckled (was Negative)
Leptin
1.4
was 4.3, lean range starts 4.7
Omega-3 Index
4.7%
was 4.6%, optimal is 5.5%+
Headline: the lipid particle picture went from her weakest area to nearly all green.
Every Cardio IQ particle marker that was flagged in Jan 2025 improved: LDL-P 1707 to 971, small LDL 281 to 131, HDL Large 5705 to 7022 (now above the 6729 optimal floor), LDL peak size 220.2 to 223.7 (now above 222.9). Only LDL Medium still touches its cut point at exactly 215. (All values: Quest HZ452364U Cardio IQ section; Jan values from the same report's Previous Result column.)
One new flag worth a doctor conversation: ANA turned positive.
Screen positive, titer 1:40 (the lowest reportable level), nuclear speckled pattern. It was negative in Jan 2025. Quest's own note: a low level ANA titer may be present in pre-clinical autoimmune diseases and normal individuals. Rheumatoid factor and both thyroid antibodies remain negative, so there is no supporting autoimmune signal elsewhere in the panel. Reasonable move: mention it to her physician and recheck at the next draw. (Source: Quest HZ452364U immunology section.)
Lipoprotein Particles (Cardio IQ, ion mobility)
May 2026 vs Jan 2025 (drawn 01/11/2025). Source: Quest HZ452364U, Cleveland HeartLab section, including its printed Previous Result column.
Marker
Jan 2025
May 2026
Optimal
Read
LDL Particle Number (nmol/L)
1,707 H
971 OPT
<1138
Crossed High to Optimal
LDL Small (nmol/L)
281 H
131 OPT
<142
Crossed High to Optimal
LDL Medium (nmol/L)
386 H
215 H
<215
Big drop, sits exactly on the cut
HDL Large (nmol/L)
5,705 L
7,022 OPT
>6729
Crossed Low to Optimal
LDL Pattern
A
A OPT
A
Unchanged, optimal
LDL Peak Size (Angstrom)
220.2 L
223.7 OPT
>222.9
Crossed into Optimal
Standard Lipids and Cardio Markers
Source: Quest HZ452364U lipid panel; Jan 2025 from her health profile (Quest 01/10/2025 draw).
Marker
Jan 2025
May 2026
Reference
Read
Total Cholesterol (mg/dL)
184
189
<200
Stable, in range
LDL-C (mg/dL)
104 H
100 H
<100
Improved, still at the cut
HDL (mg/dL)
66
70
≥50
Up, excellent
Triglycerides (mg/dL)
48
93
<150
Up but well in range
Non-HDL Cholesterol (mg/dL)
118
119
<130
Stable, in range
Chol/HDL Ratio
2.8
2.7
<5.0
Excellent
Homocysteine (umol/L)
6.1
4.9
≤11.0
Improved
Immunology
Source: Quest HZ452364U immunology section; Jan 2025 from her health profile.
Marker
Jan 2025
May 2026
Reference
Read
ANA Screen, IFA
Negative
Positive A
Negative
New, recheck next draw
ANA Titer
n/a
1:40 H
<1:40
Lowest reportable level
ANA Pattern
n/a
Nuclear, Speckled
Per report note, seen in normals too
Rheumatoid Factor (IU/mL)
<10
<10
<14
Negative
Thyroglobulin Antibodies (IU/mL)
<1
<2
≤2
Negative
Thyroid Peroxidase Antibodies (IU/mL)
<1
<1
<9
Negative
Hormones and Fertility
Source: Quest HZ452364U; Jan 2025 from the report's Previous Result column. Estradiol, LH, FSH, and prolactin swing with cycle phase, so the big moves below most likely reflect a different cycle day at draw, not a trend.
Marker
Jan 2025
May 2026
Reference
Read
AMH (ng/mL)
3.45
3.95
0.36-10.07
Ovarian reserve holding strong
Estradiol (pg/mL)
42
223
phase-dependent
Cycle phase, not a trend
FSH (mIU/mL)
7.8
2.9
phase-dependent
Cycle phase
LH (mIU/mL)
4.2
0.9
phase-dependent
Cycle phase
Prolactin (ng/mL)
7.0
5.5
3.0-30.0
Normal
DHEA Sulfate (mcg/dL)
55
38
19-237
Lower, still in range
Testosterone Total (ng/dL)
17
18
2-45
Normal
Testosterone Free (pg/mL)
1.3
1.8
0.1-6.4
Normal
SHBG (nmol/L)
108
90
17-124
In range
Omega Panel
Source: Quest HZ452364U OmegaCheck (MedFusion); Jan 2025 from the report's Previous Result column. Context: the SR Omega-3 supplement only entered her stack with the May 2026 redesign (labels uploaded to Drive 05/15/2026), 11 days before this 05/26/2026 draw. Too early to judge it here.
Marker
Jan 2025
May 2026
Reference
Read
Omega-3 Index, EPA+DPA+DHA (% by wt)
4.6 L
4.7 L
≥5.5 optimal
Still low, the open target
EPA (%)
0.4
0.4
0.2-2.3
Unchanged, low end
DHA (%)
3.1
3.3
1.4-5.1
Slightly up
DPA (%)
1.2
1.0
0.8-1.8
In range
AA/EPA Ratio
42.3 H
19.0
3.7-40.7
Back in range
Omega-6/Omega-3 Ratio
9.5
8.4
3.7-14.4
Improved
Arachidonic Acid (%)
15.0
8.3 L
8.6-15.6
Now below range, watch
Linoleic Acid (%)
25.6
27.9
18.6-29.5
In range
Metabolic and Other
Source: Quest HZ452364U; Jan 2025 from the report's Previous Result column.
Marker
Jan 2025
May 2026
Reference
Read
Leptin (ng/mL)
4.3 L
1.4 L
4.7-23.7 lean female
Dropped further below floor
Methylmalonic Acid (nmol/L)
150
72
55-335
B12 status fine
Zinc (mcg/dL)
66
71
60-130
Up from low-normal
GGT (U/L)
24
20
3-50
Good
Amylase (U/L)
66
81
21-101
In range
Lipase (U/L)
24
27
7-60
In range
Lead, venous (mcg/dL)
<1.0
<1.0
<3.5
Clean
Not in this draw (so still unverified from Jan 2025):
Vitamin D: her #1 Jan 2025 gap (26 ng/mL, insufficient). This panel did not retest it, so whether the D3+K2 fixed it is unknown. Add 25-OH-D to the next order.
CBC, fasting glucose / HbA1c / insulin, TSH / T4 / T3, iron / ferritin, hs-CRP, ApoB, Lp(a), magnesium, cortisol, uric acid: none appear in specimen HZ452364U. If Function Health ran these as a second specimen (Jan 2025 came as Parts 1 and 2), that PDF has not been received yet.
Follow-ups
Carried into her health profile (30-personal/health/alyssa-health-profile.md).
Item
Why
Mention the positive ANA (1:40, speckled) to her physician; recheck next draw
New since Jan 2025; low titer can be normal but it changed
Check her Function Health portal for a second May results PDF
Vitamin D, CBC, metabolic, and thyroid markers are missing from this specimen
Recheck omega-3 index after 3+ months on SR Omega-3
The stack redesign landed 11 days before this draw (labels in Drive 05/15/2026, draw 05/26/2026), too early to show
Watch leptin alongside diet
1.4 vs lean-female floor of 4.7, second consecutive low and lower than Jan